This paper examines a looming reproducibility crisis in the core of the hard sciences. Namely, it concentrates on molecular modeling and simulation (MMS), a family of methods that predict properties of substances through computing interactions on a molecular level and that is widely popular in physics, chemistry, materials science, and engineering. The paper argues that in order to make quantitative predictions, sophisticated models are needed which have to be evaluated with complex simulation procedures that amalgamate theoretical, technological, and social factors (...) – leading to problems with reproducibility. Thus, for methodological reasons, the predictive success causes a reproducibility problem. (shrink)

Driven by the use cases of PubChemRDF and SCAIView, we have developed a first community-based clinical trial ontology (CTO) by following the OBO Foundry principles. CTO uses the Basic Formal Ontology (BFO) as the top level ontology and reuses many terms from existing ontologies. CTO has also defined many clinical trial-specific terms. The general CTO design pattern is based on the PICO framework together with two applications. First, the PubChemRDF use case demonstrates how a drug Gleevec is linked to multiple (...) clinical trials investigating Gleevec’s related chemical compounds. Second, the SCAIView text mining engine shows how the use of CTO terms in its search algorithm can identify publications referring to COVID-19-related clinical trials. Future opportunities and challenges are discussed. (shrink)

Over the last decade the modeling and the storage of biological data has been a topic of wide interest for scientists dealing with biological and biomedical research. Currently most data is still stored in text files which leads to data redundancies and file chaos.In this paper we show how to use relational modeling techniques and relational database technology for modeling and storing biological sequence data, i.e. for data maintained in collections like EMBL or SWISS-PROT to better serve the needs for (...) these application domains.For this reason we propose a two step approach. First, we model the structure (and therefore the meaning of the) data using an Entity-Relationship approach. The ER model leads to a clean design of a relational database schema for storing and retrieving the DNA and protein data extracted from various sources. Our approach provides the clean basis for building complex biological applications that are more amenable to changes and software ports than their file-base counterparts. (shrink)

"Welche Bedeutung kommt der Dimension des Leibes im Religiösen zu und mit welchen Begriffen lässt sie sich beschreiben? Zwei der aussichtsreichsten Diskurspartner in dieser Frage sind Johann Gottlieb Fichte und Emmanuel Levinas. Ihre Beiträge werden erschlossen, auf ihre philosophische Plausibilität hin befragt und in einen Dialog miteinander gebracht. Die dabei erarbeiteten Kategorien werden in ihrer grundsätzlichen Eignung für eine christlich-theologische Reflexion überprüft und exemplarisch auf zwei Praxisfelder angewendet: Eucharistie und Kontemplation."-- Back cover.

This collection reflects the result of interactive academic work initiated by Johann Heinrich Pestalozzi University Inc., Miami, Florida, during the academic year 2018, and also the scholarly work of academics supporting our University. The authors include international academics from the United States of America, Great Britain, Croatia, Bosnia-Herzegovina, Switzerland, Austria, Serbia and Macedonia. Table of Contents: About the Authors; Craig Paterson--Contextualism & the History of Philosophy; Darko Bekic--Triangle Concept of Unification-Demilitarization Neutralisation of Korea: An Outline; Orlando Mardner--Economic Dimensions of (...) Armed Groups & Intra-State Terrorism: Preventions Through Geostrategic Changes in the International Laws of Financial Systems; Stephan U. Breu--The Challenge of Educating Refugee Children to Avoid Creating Tomorrow's Extremists; Hatidza Berisa--Historical Context of Military Interventionism; Parvis Hanson--The Future of Globalization: Help or Hurt the World's Poor; Joseph P. Garske--Common Law & Civilian Legal Cultures: Finding A Language of Law for the Global Age; Craig Paterson--The Societas Civilitas, Hate Speech & State Imposed Restrictions; Elmar Kuhn --Education as the Key for a Global Society in Peace & Freedom; Manish Sharma--Global Ecology & Sustainable Development: A Study in Gandhian Perspective; Paul Borrow-Longain--Law of Heraldic Arms; Craig Paterson--William Tyndale's Publication of The New Testament in the English Vernacular; Milka Ristova & Sanja Angelovska--The Contributions of International Law & NonGovernmental Organizations in Facilitating the Peaceful Reunification of the Korean Peninsula; Stephan U. Breu--Blockchains & Cybercurrencies Challenging Anti-Trust & Competition Law; Zoran R. Vitorovic--Preventive Diplomacy as a Key for the Reduction of Asymetric Conflicts; Stephan U. Breu--International Law Under Attack by Geostrategic Tensions Between Leading Nations. (shrink)

IntroductionE.J. LOWE: Event Causation and Agent CausationRalf STOECKER: Agents in ActionGeert KEIL: How Do We Ever Get Up? On the Proximate Causation of Actions and EventsMaria ALVAREZ: Letting Happen, Omissions, and CausationFrederick STOUTLAND: Responsive Action and the Belief-Desire ModelMarco IORIO: How Are Agents Related to Their Actions? The Existentialist ResponseJens KULENKAMPFF: What Oedipus Did When He Married Jocasta or What Ancient Tragedy Tells Us About Agents, Their Actions, and the WorldRüdiger BITTNER: Agents as RulersMonika BETZLER: How Can an Agent Rationally (...) Guide His Actions?Martina HERRMANN: Competence, Options, and RelationsWeitere Abhandlungen/Further ArticlesEduardo FERMANDOIS: Kommunikation ohne Sprache? Zu Davidsons später SprachphilosophieGuido IMAGUIRE: Die Form der Externalität in Russells An Essay on the Foundations of Geometry und die Ursprünge seiner RelationstheorieBuch-Symposium/Book-SymposiumJohn BICKLE: Precis of Psychoneural Reduction: The New WaveAnsgar BECKERMANN: Physicalism and New Wave ReductionismJ. Christopher MALONEY: Reservations about New Wave ReductionAchim STEPHAN: How to Lose the Mind-Body ProblemJohn BICKLE: New Wave Metascience. Replies to Beckermann, Maloney, and StephanBuchnotizen/Critical NotesEingesandte Bücher/Books Received. (shrink)

Identitat ist unter den Bedingungen der Postmoderne kein festes Ganzes mehr. Die unuberschaubare Anzahl an Moglichkeiten in Ausbildung, Studium, Beruf, aber auch Partnerschaft und Lebensformen fuhren zu der Einsicht, dass Identitat sich immer neu konstituieren muss. Tatsachlich ist Identitat das, was mich als unverwechselbares Ich korperlich und geistig - und das heisst: leiblich - konstituiert. Zugleich entzieht sie sich mir und muss immer wieder neu errungen werden. Dies gilt gerade dann, wenn fruhere Ideale zusammenbrechen oder das zuvor Selbstverstandliche nicht mehr (...) tragt. Identitat und Identitatsbildung betreffen den Einzelnen ebenso wie politische oder religiose Gemeinschaften. In Zeiten, in denen vieles in Bewegung ist, ist Identitat eng verbunden mit der Frage nach den gemeinsamen Werten - das, wofur es sich zu leben lohnt und was wir an die nachste Generation weitergeben mochten. Besondere Beachtung verdienen in diesem Kontext phanomenologische Ansatze, die den leiblichen, sinnlichen und affektiven Dimensionen des Lebens Rechnung tragen. Auf diese Weise lassen sich Erfahrungen, die unsere Identitat begrunden und ausmachen, als Momente einer breiter angelegten Spiritualitat der Wahrnehmung verstehen. Mit Beitragen von Johannes Bundgens, Natalie Depraz, Stephan Gratzel, Caroline Horch, Antje Kapust, Rolf Kuhn, Elmar Nass, Simone Paganini, Michaela Puzicha, Bertin Rautenberg, Holger Zaborowski u. a. (shrink)

Inhalt: Rainer ADOLPHI: Weltbild und Ich-Verständnis. Die Transformation des >Primats der praktischen Vernunft< beim späteren Fichte. Jacinto RIVERA DE ROSALES: Das Absolute und die Sittenlehre von 1812. Sein und Freiheit. Marek J. SIEMEK: Fichtes und Hegels Konzept der Intersubjektivität. Ewa NOWAK-JUCHACZ: Das Anerkennungsprinzip bei Kant, Fichte und Hegel. Ronald MATHER: On the Concepts of Recognition. Makoto TAKADA: Verwandlung der Individuumslehre bei Fichte. Hans Georg von MANZ: Deduktion und Aufgabe des individuellen Ich in Fichtes Darstellungen der Wissenschaftslehre von 1810/11. Jürgen STAHL: (...) Zur Kultur in der Vermittlungsrolle zwischen empirischem und absolutem Ich. Christoph ASMUTH: Metaphysik und Historie bei J.G. Fichte. Stephan GNÄDINGER: Vorsehung. Ein religionsphilosophisches Grundproblem bei J.G. Fichte. Johannes HEINRICHS: Die Mitte der Zeit als Tiefpunkt einer Parabel. Fichtes Geschichtskonstruktion und Grundzüge der gegenwärtigen Zeitenwende. Marco M. OLIVETTI: Zum Religions- und Offenbarungsverständnis beim jungen Fichte und bei Kant. (shrink)

Johann Gottfried Herder (1744-1803) gilt weithin als Autor des literarischen Sturm und Drang bzw. der philosophischen und theologischen Spataufklarung. Dass er jedoch auf vielen Gebieten die Klassische Deutsche Philosophie massgeblich beeinflusste, wird eher selten in den Blick genommen. Der Band untersucht dieses sowohl kritische als auch affirmative Rezeptionsverhaltnis Kants, Schellings, Schlegels, Humboldts oder Hegels zu Herder auf den Gebieten der Geschichtsphilosophie, der Metaphysik, der Ethik und Politik sowie der Asthetik und Anthropologie. - Mit Beitragen von Andreas Arndt, Manfred Baum, (...) Christoph Binkelmann, Martin Bondeli, Nigel De Souza, Stefan Greif, Andree Hahmann, Cornelia Klinger, Christian Krijnen, Stephan Nachtsheim, Angelica Nuzzo, Ludger Roth, Gideon Stiening, Violetta Stolz und Gunter Zoller. (shrink)

It is often claimed that the greatest value of the Bayesian framework in cognitive science consists in its unifying power. Several Bayesian cognitive scientists assume that unification is obviously linked to explanatory power. But this link is not obvious, as unification in science is a heterogeneous notion, which may have little to do with explanation. While a crucial feature of most adequate explanations in cognitive science is that they reveal aspects of the causal mechanism that produces the phenomenon to be (...) explained, the kind of unification afforded by the Bayesian framework to cognitive science does not necessarily reveal aspects of a mechanism. Bayesian unification, nonetheless, can place fruitful constraints on causal–mechanical explanation. 1 Introduction2 What a Great Many Phenomena Bayesian Decision Theory Can Model3 The Case of Information Integration4 How Do Bayesian Models Unify?5 Bayesian Unification: What Constraints Are There on Mechanistic Explanation?5.1 Unification constrains mechanism discovery5.2 Unification constrains the identification of relevant mechanistic factors5.3 Unification constrains confirmation of competitive mechanistic models6 ConclusionAppendix. (shrink)

Unter den Versuchen Fichtes, sein Denken allgemeinverständlich darzustellen, zählt diese 1800 erschienene Schrift zu den inhaltlich abgerundetsten und aufschlußreichsten; bei den Zeitgenossen stieß sie jedoch auf vehemente Kritik, Hegel sah in ihr gar einen besonders illustrativen Text für den Aufweis der Haltlosigkeit der von Fichte in der Wissenschaftslehre vertretenen Position einer auf das Ich als Tathandlung gegründeten Philosophie. Darum vermag allein schon die Lektüre von Fichtes Bestimmung des Menschen und ihrer kritischen Rezeption in Hegels Glauben und Wissen einen Einblick in (...) die Gründe zu vermitteln, warum bis ins 20. Jahrhundert die Philosophie Fichtes weitgehend als ein merkwürdiger Mosaikstein auf dem Wege "Von Kant bis Hegel" oder, im Hinblick auf den "Endpunkt" dieses Wegs wohl genauer, in der "Entwicklung des Spinozismus" betrachtet wurde. Deutlich wird einer neuen Lektüre aber auch, wieviel noch zu tun bleibt, um die wichtigen Erkenntnisse, die im Deutschen Idealismus auf so getrennten Bahnen gewonnen wurden, im Blick auf die gemeinsamen Grundprobleme einer "Ersten Philosophie" ohne Rückfall in die traditionellen Feindbilder wahrzunehmen und kritisch in die pluralistische Diskussion heutigen Philosophierens einzubringen. (shrink)

In the past decade well-designed research studies have shown that the practice of collaborative philosophical inquiry in schools can have marked cognitive and social benefits. Student academic performance improves, and so too does the social dimension of schooling. These findings are timely, as many countries in Asia and the Pacific are now contemplating introducing Philosophy into their curricula. This paper gives a brief history of collaborative philosophical inquiry before surveying the evidence as to its effectiveness. The evidence is canvassed under (...) two categories: schooling and thinking skills; and schooling, socialisation and values. In both categories there is clear evidence that even short-term teaching of collaborative philosophical inquiry has marked positive effects on students. The paper concludes with suggestions for further research and a final claim that the presently-available research evidence is strong enough to warrant implementing collaborative philosophical inquiry as part of a long-term policy. (shrink)

If one formulates Helmholtz’s ideas about perception in terms of modern-day theories one arrives at a model of perceptual inference and learning that can explain a remarkable range of neurobiological facts. Using constructs from statistical physics it can be shown that the problems of inferring what cause our sensory inputs and learning causal regularities in the sensorium can be resolved using exactly the same principles. Furthermore, inference and learning can proceed in a biologically plausible fashion. The ensuing scheme rests on (...) Empirical Bayes and hierarchical models of how sensory information is generated. The use of hierarchical models enables the brain to construct prior expectations in a dynamic and context-sensitive fashion. This scheme provides a principled way to understand many aspects of the brain’s organisation and responses. In this paper, we suggest that these perceptual processes are just one emergent property of systems that conform to a free-energy principle. The free-energy considered here represents a bound on the surprise inherent in any exchange with the environment, under expectations encoded by its state or configuration. A system can minimise free-energy by changing its configuration to change the way it samples the environment, or to change its expectations. These changes correspond to action and perception, respectively, and lead to an adaptive exchange with the environment that is characteristic of biological systems. This treatment implies that the system’s state and structure encode an implicit and probabilistic model of the environment. We will look at models entailed by the brain and how minimisation of free-energy can explain its dynamics and structure. (shrink)

These selections provide a brief but comprehensive introduction to Fichte’s philosophical system and his place in the history of German Idealism. In addition to some of Fichte’s most influential texts, such as the First and Second Introductions to the Wissenschaftslehre and The Basis of Our Belief in a Divine Governance of the World, Breazeale has translated, for the first time into English, several other writings from the same period, including Attempt at a New Presentation of the Wissenschaftslehre, Other short essays, (...) including Fichte’s replies to the charge of atheism, extend the discussions of the Introductions and respond to criticisms. Breazeale’s substantial Introduction supplies the context needed for a sound appreciation of Fichte’s enterprise and achievement. (shrink)

Johann Gottfried von Herder is one of the most important German philosophers of the eighteenth century, who had enormous influence on later thinkers such as Hegel, Schleiermacher and Nietzsche. His wide-ranging ideas were formative in the development of linguistics, hermeneutics, anthropology and bible scholarship, and even today they retain their vitality and relevance to an extraordinary degree. This volume presents a translation of Herder's most important and characteristic philosophical writings in his areas of central interest, including philosophy of language, (...) philosophy of mind, philosophy of history and political philosophy, as well as his general philosophical program. An introduction sets the writings in their historical context and examines their philosophical achievement. (shrink)

There is currently disagreement about whether the phenomenon of first-person, or de se, thought motivates a move towards special kinds of contents. Some take the conclusion that traditional propositions are unable to serve as the content of de se belief to be old news, successfully argued for in a number of influential works several decades ago.1 Recently, some philosophers have challenged the view that there exist uniquely de se contents, claiming that most of the philosophical community has been under the (...) grip of an attractive but unmotivated myth.2 At the very least, this latter group has brought into question the arguments in favor of positing special kinds of content for de se belief; I think they have successfully shown that these arguments are not as conclusive, or fully articulated, as many have taken them to be. In this paper I will address these challenges directly and I will present and defend an argument for the conclusion that the phenomenon of de se thought does indeed motivate the move to a special kind of content, content that is uniquely de se. First, I characterize a notion of de se belief that is neutral with respect to friends and foes of uniquely de se content. I then argue for a determination thesis relating de se belief to belief content: that there is no difference in de se belief without a difference in belief content. I argue that various proposals for rejecting this determination thesis are unsuccessful. In the last part of the paper, I employ this determination thesis to argue for the existence of a type of belief content that is uniquely de se. (shrink)

Metaphysical grounding is standardly taken to be irreflexive: nothing grounds itself. Kit Fine has presented some puzzles that appear to contradict this principle. I construct a particularly simple variant of those puzzles that is independent of several of the assumptions required by Fine, instead employing quantification into sentence position. Various possible responses to Fine's puzzles thus turn out to apply only in a restricted range of cases.

We define a notion of difference-making for partial grounds of a fact in rough analogy to existing notions of difference-making for causes of an event. Using orthodox assumptions about ground, we show that it induces a non-trivial division with examples of partial grounds on both sides. We then demonstrate the theoretical fruitfulness of the notion by applying it to the analysis of a certain kind of putative counter-example to the transitivity of ground recently described by Jonathan Schaffer. First, we show (...) that our conceptual apparatus of difference-making enables us to give a much clearer description than Schaffer does of what makes the relevant instances of transitivity appear problematic. Second, we suggest that difference-making is best seen as a mark of good grounding-based explanations rather than a necessary condition on grounding, and argue that this enables us to deal with the counter-example in a satisfactory way. Along the way, we show that Schaffer's own proposal for salvaging a form of transitivity by moving to a contrastive conception of ground is unsuccessful. We conclude by sketching some natural strategies for extending our proposal to a more comprehensive account of grounding-based explanations. (shrink)

The time and opportunity have finally arrived for the next phase of Septuagint research. Even though not all the books of the LXX have been completed by the Septuaginta-Unternehmen in Göttingen, by far the largest number of books have been assigned and are being prepared. Thus, text-critical work has largely been completed, or is in the process of being prepared. The next phase, hermeneutical research, is at hand. This phase naturally requires correct methodology. This applies to an acceptable textual theory (...) as well as to the reconstruction of the textual history of the LXX. This article takes the Septuagint of Proverbs as its point of comparison and discusses the following issues: novel research (monographs) and new research projects in conjunction with existing projects (exegetical commentaries, a theology of the Septuagint). (shrink)

Johann Nikolaus Tetens s Philosophical inquiries into Human Nature and its Development (1777) is one of the most important philosophical works of the late Enlightenment. In 14 essays, Tetens attempts to resolve the fundamental problems of Enlightenment philosophy. This is the first complete and annotated edition of this major work of late Enlightenment empiricism since its initial publication.".

Bd. 1. Briefwechsel 1775-1793 -- Bd. 2. Briefwechsel 1793-1795 --Bd. 4. Briefwechsel 1799-1800 -- Bd. 5. Briefwechsel 1801-1806 -- Bd. 6. Briefwechsel 1806-1810 -- Bd. 7. Briefwechsel 1810-1812 -- Bd. 8. Briefwechsel 1812-1814, Anhang 1815-1818, Nachträge 1789-1810.

Bd. 1. Briefwechsel 1775-1793 -- Bd. 2. Briefwechsel 1793-1795 --Bd. 4. Briefwechsel 1799-1800 -- Bd. 5. Briefwechsel 1801-1806 -- Bd. 6. Briefwechsel 1806-1810 -- Bd. 7. Briefwechsel 1810-1812 -- Bd. 8. Briefwechsel 1812-1814, Anhang 1815-1818, Nachträge 1789-1810.